[<sup>68</sup>Ga]Ga-PSMA PET/MRI, histological PSMA expression and preliminary experience with [<sup>177</sup>Lu]Lu-PSMA therapy in relapsing high-grade glioma.

Front Oncol · 2022 · PMC9478729 · PMID 36119502

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showed a trendno p-value reported

In the three patients eligible for [ 177 Lu]Lu-PSMA therapy, PSMA staining exhibited a higher H-score of 65 (62.5-77.5) in endothelial cells compared to 30 (17.5-52.5) in the patients who were not eligible for [ 177 Lu]Lu-PSMA therapy ( p = 0.08) and a linear regression analysis showed a trend for higher endothelial but not tumor cell PSMA expression in patients with increased [ 68 Ga]Ga-PSMA uptake ( Figure 2 ).

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