We then prioritized 13 CpGs in females and 6 CpGs in males by additionally requiring these CpGs to also be nominally significant (i.e., P- value < 0.05) in the separate sex-specific meta-analyses of brain and blood samples (Tables 5 a and 6 ).
The results of our expanded logistic regression model that additionally included smoking score showed all 27 sex-specific CpGs (Supplementary Table 2 ) remained highly significant, with meta-analysis P- values ranging from 2.59 × 10 −5 to 5.83 × 10 −8 (Supplementary Table 15 ), indicating these CpGs are associated with AD independent of smoking.