Adolescent self-administration of the synthetic cannabinoid receptor agonist JWH-018 induces neurobiological and behavioral alterations in adult male mice.

( 2017 ) demonstrated that chronic administration of THC during adolescence increased nestlet shredding during adulthood; however, adolescence animals showed a trend to statistical significance in burying marbles only immediately after THC treatment.

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In the cortex of adult mice exposed to JWH-018 as adolescents, we found an increasing trend in IL4 levels and an increase in RANTES, a chemotactic cytokine that directs leukocytes to sites of inflammation and infection, along with a decrease in IL2 and IL13 expression compared to vehicle mice.

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