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Elevated homocysteine activates unfolded protein responses and causes aberrant trophoblast differentiation and mouse blastocyst development.

Physiol Rep · 2022 · PMC9483615 · PMID 36117391

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These data suggest that increased apoptosis is likely a major contributor to the reduced TE cell number in HCY‐treated blastocysts, although they failed to reach statistical significance. 3.2.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.