Association of antipsychotic use with breast cancer: a systematic review and meta-analysis of observational studies with over 2 million individuals.

Introduction Antipsychotic medications are widely prescribed for people living with mental disorders such as schizophrenia, bipolar disorder, major depressive disorder and dementia, with an increasing trend of off-label use also observed worldwide in recent decades (Hálfdánarson et al. , 2017 ; Ng et al. , 2021 ).

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non-use) with breast cancer with a >30% increased risk observed, although the pooled OR did not reach statistical significance (HR 1.39, 95% CI 1.11–1.73; OR 1.37, 95% CI 0.90–2.09).

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