Genome-wide Association and Meta-analysis of Age at Onset in Parkinson Disease: Evidence From the COURAGE-PD Consortium.

9 A previous study also reported a borderline significant association of the variant rs429358, representing the APOE ε4 locus with PD-AAO ( p = 5.69 × 10 −8 ) in a combined dataset (n = 28,568) comprising IPDGC and 23andMe datasets. 7 The study, however, suggested that the association at the locus could be an age-related effect, with a highly significant association with the age of controls ( p = 1.49 × 10 −5 ).

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However, the association was primarily driven by highly significant findings in the IPDGC dataset (β(SE) IPDGC = 0.754(0.171), p IPDGC = 9.86 × 10 −6 ; β(SE) COURAGE‐EUR = 0.599(0.275), p COURAGE‐EUR = 0.029).

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Nevertheless, the SNCA variant also showed a trend toward association (rs356203: β(SE) COURAGE = 0.362(0.172), p COURAGE = 0.035).

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