Single nuclei transcriptomics of muscle reveals intra-muscular cell dynamics linked to dystrophin loss and rescue.

Many of these differentially expressed genes were also differentially expressed between mdx and e23AON-treated myofiber nuclei (68% in type IIx, 41% in type IIa, 78% in type IIb), with a strong trend toward e23AON-treated nuclei recovering a more WT gene expression (Fig. 3c ).

also in 5,725 other papers

There was an overall trend that differentially expressed (DE) genes between corresponding populations in mdx and mdx e23AON, acquired a more ‘WT-like’ expression level with e23AON treatment.

also in 4,871 other papers