Long-term experience in the treatment of α1-antitrypsin deficiency: 25 years of augmentation therapy.

Compared with placebo, AAT augmentation therapy had a highly significant effect on the number of severe exacerbations (requiring corticosteroids or hospitalisation) (6.7% versus 13.5%; p=0.013) [ 13 ].

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As in the previous study [ 12 ], the effect of AAT augmentation therapy was not significantly different from that of placebo but a clear trend towards an effect on lung density was observed (p=0.068) ( fig. 3 ).

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