Adverse childhood experience and asthma onset: a systematic review.

10 of the 12 studies reported statistically significant effects of early life stress on asthma onset with odds ratios ranging from borderline significance to exceeding double the baseline measure.

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At 7-year follow-up, the authors report a mildly significant effect (OR 1.25) with subsequent analyses revealing a dose–response relationship between intensity and severity of mental health difficulties and likelihood of asthma diagnosis.

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This study found a highly significant effect of behavioural difficulties preceding the onset of parent-reported wheeze (OR 8.95).

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