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Genomic Classification of HER2-Positive Patients With 80-Gene and 70-Gene Signatures Identifies Diversity in Clinical Outcomes With HER2-Targeted Neoadjuvant Therapy.

JCO Precis Oncol · 2022 · PMC9489196 · PMID 36108259

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However, as concluded in the 6-year interim analysis of APHINITY, longer follow-up may be needed to assess OS, which did not reach statistical significance in either study. 21 Together, these data suggest that the population of patients who benefit most from dual HER2-targeted therapy has genomically defined HER2-Type breast cancer.

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