Longitudinal profiles of plasma gelsolin, cytokines and antibody expression predict COVID-19 severity and hospitalization outcomes.

Meanwhile, combining pGSN with IL-6 (AUC=0.904; p=0.003) showed a more significant ability to predict mild COVID-19 and IP-10 (AUC=0.754; p=0.065), HGF (AUC=0.746; p=0.075) and TGF-β1 (AUC=0.765; p=0.078) demonstrated a trend toward significance ( Figure 5A ; Supplementary Figure S4C ) .

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Mild COVID-19 patients had significantly high pGSN/IL-6 amongst all the multi-analyte markers following day 4 of symptoms onset compared with moderate and severe COVID-19 patients, and pGSN/IP-10 and pGSN/HGF showed a trend toward this association ( Figure 3A ; Supplementary Figure S2A ) .

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