Different oxytocin and corticotropin-releasing hormone system changes in bipolar disorder and major depressive disorder patients.

EBioMedicine · 2022 · PMC9489957 · PMID 36126617

Europe PMC DOI

hedged sentences

0.0060

closest p · 0.1× alpha

0.0560

boldest claim

The sentences

highly significantp= 0·006actually significant

In addition, a highly significant increased ratio of OXT-ir/CRH-ir was found in BD ( p= 0·006, Mann-Whitney U test, Figure 2 i), but not in MDD, patients compared with their respective controls.

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showed a trendp= 0·056so close (0.05 < p ≤ 0.1)

On the other hand, MDD patients but not BD patients showed a trend of lower CRHR2-mRNA in the DLPFC ( p= 0·056, Mann-Whitney U test, Cohen's d=-0·71, Figure 3 e-h, Table 3 ) compared with their controls.

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