Cannabidiol counters the effects of a dominant-negative pathogenic Kv7.2 variant.

Here, an equivalent time point comparison at 15 min revealed that CBD invoked a highly significant negative shift in Va from a baseline value in control recordings of Kv7.2 wt + Kv7.3 of −29.8 ± 1.25 mV to −35.6 ± 1.36 mV (n = 8; p = 1.06 × 10 −5 ) in CBD ( Figure 5 A).

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The total Kv7.2 protein level showed a trend of increasing for the homomeric Kv7.2 channels, and was significantly increased in cells coexpressing Kv7.2mut + Kv7.3 channels compared to Kv7.2 wt + Kv7.3 (1.52 ± 0.13, n = 5, p = 0.00729) ( Figure 2 E).

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