Practical Considerations for the Management of Cancer-Associated Venous Thromboembolism: A Guide for the General Oncology Practitioner.

In terms of the risk of major bleeding, this was numerically higher with DOACs; however, the difference did not reach statistical significance (RR 1.17, 95% CI, 0.82–1.67; p = 0.39; I 2 = 12%), and the absolute risk increase in major bleeding with DOACs was 0.6% (95% CI, from −0.7 to 2.5) [ 24 ].

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