borderline significancep = 0.05
cured CE We found higher OPR/LBR (OR 5.33, 95% CI 2.41–11.79, I 2 = 0%, p < 0.0001) and CPR (OR 3.64, 95% CI 1.89–7.04, I 2 = 0%, p = 0.0001) in patients with cured CE in comparison to those with untreated/persistent CE (data from four studies [ 4 , 8 , 12 , 34 ]), with borderline significance in terms of MR ( p = 0.05) ( Figure 3 a–c).