SIRT5 is a proviral factor that interacts with SARS-CoV-2 Nsp14 protein.

PLoS Pathog · 2022 · PMC9499238 · PMID 36095012

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did not reach statistical significanceno p-value reported

Other markers such as STAT3 , IFIT3 and B2M showed modest but statistically significant upregulation ranging from 20 to 70%, while IFITM2 and SCNA had increased expression that did not reach statistical significance.

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highly significantno p-value reported

This upregulation was modest but highly significant and may account for why SARS-CoV-2 propagated slower in SIRT5 -KO cells.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.