However, given that we selected the gene sets in this study based on interactions with the candidate directional anchor gene, we tested four different p value thresholds ( P T | T = 0.005 , 0.05 , 0.5 , 1 ), which represent a model with all SNPs, nominally significant SNPs, and a threshold an order of magnitude above or below the nominal threshold.
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Genetics-informed precision treatment formulation in schizophrenia and bipolar disorder.
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Specifically, all of the network BIP PESs were significantly higher in affected individuals, with the exception of the FADS1 network PES for which there was only a trend towards significance.