A Metabolomics Approach for Predicting OATP1B-Type Transporter-Mediated Drug-Drug Interaction Liabilities.

The levels of GCDCA-S, another bile acid previously proposed as an OATP1B substrate, were also modestly increased in manner dependent on the paclitaxel dose ( Figure 3 E), although the differences did not reach statistical significance ( Figure 3 F).

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