Quantification of APOBEC3 Mutation Rates Affecting the <i>VP1</i> Gene of BK Polyomavirus In Vivo.

Interestingly, the three patients with the highest mean APOBEC3A/B mutation rate stood out from this trend, and if data from these three patients were excluded, then the association between APOBEC3A/B and SBS89 mutation rates became highly significant ( p < 0.001). 3.3.

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Compared to plasmid controls, the number of SBS89 mutations per 104 read pairs was significantly higher in plasma and urine samples, and although the same tendency was seen for kidney biopsies, it did not reach statistical significance ( Figure 1 C), possibly due to the low number of biopsy samples analyzed.

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