Pharmacogenetics of Cardiovascular Prevention in Diabetes: From Precision Medicine to Identification of Novel Targets.

J Pers Med · 2022 · PMC9504677 · PMID 36143187

Europe PMC DOI

hedged sentences

0.0004

closest p · 0.0× alpha

0.0004

boldest claim

The sentences

highly significantp = 0.0004actually significant

In contrast, subjects carrying either of the other two genotypes did not derive any benefit from this treatment, resulting in a highly significant SNP x fenofibrate interaction ( p = 0.0004).

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a clear trendno p-value reported

It should be noted that the CAD-PGRS used in these studies were different (based on 27 SNPs associated with CAD in FOURIER and based on six million variants in the ODYSSEY), yet they were both characterized by a clear trend for interaction with PCSK9i treatment (reported as significant in FOURIER and estimated to be significant in ODYSSEY).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.