Are the Bacteria and Their Metabolites Contributing for Gut Inflammation on GSD-Ia Patients?

Using two distinct metrics of diversity, borderline significance was obtained for propionic acid, affecting the microbial structure on Euclidean basis in 8% (r 2 = 0.081; p = 0.079), and for lactic acid, affecting 6% of microbial structure using Bray–Curtis distance (r 2 = 0.065; p = 0.060).

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Although there was no difference in bacterial metabolite levels between the patients and controls for LA and PA, these metabolites alone reached borderline significance and had an interesting effect size on the microbial structure (6.5% and 8%, respectively).

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