Activation of Alternative Bilirubin Clearance Pathways Partially Reduces Hyperbilirubinemia in a Mouse Model Lacking Functional Ugt1a1 Activity.

We observed the up-regulation of Cyp2a5 protein expression along with up-regulated enzyme activity in the liver of KO animals, in comparison to WT animals while mRNA levels showed a trend toward up-regulation ( Figure 2 B,D).

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