Preparation of Solid Self-Nanoemulsifying Drug Delivery Systems (S-SNEDDS) by Co-Extrusion of Liquid SNEDDS and Polymeric Carriers-A New and Promising Formulation Approach to Improve the Solubility of Poorly Water-Soluble Drugs.

Pharmaceuticals (Basel) · 2022 · PMC9505398 · PMID 36145356

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a clear trendno p-value reported

Particularly with the celecoxib- and the efavirenz S-SNEDDS, there was a clear trend toward decreasing drug solubility with the increasing M w of the polymer, and solubilities were, in several cases, lower than those obtained with the L-SNEDDS formulation.

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