Demographics, Radiological Findings, and Clinical Outcomes of <i>Klebsiella pneumonia</i> vs. Non-<i>Klebsiella pneumoniae</i> Pyogenic Liver Abscess: A Systematic Review and Meta-Analysis with Trial Sequential Analysis.

Pathogens · 2022 · PMC9505935 · PMID 36145408

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did not reach statistical significanceno p-value reported

N-KPPLA n = 1/297 (0.3%), OR 2.80, 95% CI: 0.84, 9.34, p = 0.09) ( Figure S4C ) and brain abscess/meningitis (KPPLA n = 10/397 (2.5%), N-KPPLA n = 0/267, OR 3.22, 95% CI: 0.68, 15.19, p = 0.14) ( Figure S4D ) compared to N-KPPLA, though this did not reach statistical significance.

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may not be significantno p-value reported

Repetitive testing of significance by pooling of results in the meta-analysis may have resulted in the rejection of null hypothesis and type 1 error (i.e., demonstrating that there is statistically significant lower mortality in KPPLA even though the results may not be significant).

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