Pairwise genetic meta-analyses between schizophrenia and substance dependence phenotypes reveals novel association signals with pharmacological significance.

Transl Psychiatry · 2022 · PMC9508072 · PMID 36151087

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We then restricted these genes to those which were also at least nominally significant ( P < 0.05) in the individual GWAS for schizophrenia and SUD but did not survive multiple-testing correction for either of the respective univariable GWAS (schizophrenia + AD = 16, schizophrenia + CUD = 15, schizophrenia + ND = 5, schizophrenia + OD = 13, Supplementary Tables 6 – 9 ).

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