29 A recent publication of two phase 3 clinical trials in subjects with severe asthma found ‘consistent and modest reductions in exacerbation rates in both studies’, around 22%, although this failed to reach statistical significance. 30 Collectively these data provide a rationale for the investigation of drugs targeting PGD 2 -CRTH2 signalling in asthma.
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Effect of CRTH2 antagonism on the response to experimental rhinovirus infection in asthma: a pilot randomised controlled trial.
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