Early life maternal separation induces sex-specific antidepressant-like responses but has minimal effects on adult stress susceptibility in mice.

When the data were analyzed separately by sex, the effects of ELS on immobility time in males did not quite reach significance [ F (1, 41) = 4.077, p = 0.051], but a history of MS did significantly increase time spent immobile in females [ F (1, 34) = 5.681, p = 0.023].

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There was a trend toward an effect of adult stress condition on center distance [ F (1, 76) = 3.74, p = 0.057, Figure 2H ], where the control group traveled a greater distance in the center than the group exposed to 3DS, but this did not reach statistical significance.

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