The nearly significant and non-significant association of C3a and C5a levels with the presence of B2-CIC, respectively, may be due to the short half-life of these complement activation products [a half-life of 30 minutes for C3a and 5 minutes for C5a has been described ( 47 – 49 )].
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Circulating immune-complexes of IgG/IgM bound to B2-glycoprotein-I associated with complement consumption and thrombocytopenia in antiphospholipid syndrome.
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