Given that systemic IL-6 regulation alterations may be significant in the establishment of central nervous system lesions [ 82 ], reductions in this cytokine may have substantial clinical outcomes in people with MS.
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IL-6 and TNF-α responses to acute and regular exercise in adult individuals with multiple sclerosis (MS): a systematic review and meta-analysis.
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Meta-analysis showed that IL-6 levels were lower after exercise but did not reach statistical significance (Table 3 , Fig. 2 A).