Loss of heat shock factor 1 promotes hepatic stellate cell activation and drives liver fibrosis.

After 6 weeks of CCl 4 administration, F4/80 expression (Figure 5B ) was significantly reduced, whereas DDC diet in Hsf1 −/− fibrotic livers showed a trend toward increased F4/80 (Figure 5B ).

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Similarly, Hsf1 −/− mice challenged with CCl 4 for 2 weeks displayed a decreasing trend in mRNA expression of F4/80 when compared with WT (Figure S4A ).

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