Barely Significant
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Alpha-1 antitrypsin Pi∗Z allele is an independent risk factor for liver transplantation and death in patients with advanced chronic liver disease.

JHEP Rep · 2022 · PMC9513767 · PMID 36176936

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showed a trendno p-value reported
11 study, which did not account for portal hypertension at the time of study inclusion and only showed a trend towards an increase in liver-related death or requirement for liver transplantation in patients harbouring the Pi∗MZ genotype.

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