Monocentric evaluation of Ki-67 labeling index in combination with a modified RPA score as a prognostic factor for survival in IDH-wildtype glioblastoma patients treated with radiochemotherapy.

EGFRvIII expression was only borderline significant for the overall collective ( p = 0.050, data not shown).

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In Kaplan–Meier survival analysis, patients with a reduction of Ki-67 LI upon progression or recurrence (Ki-67 LI quotient > 1) showed a longer OS of 23.1 (17.4–24.5) months compared to 19.5 (12.6–26.5) months for patients with a stable or increased Ki-67 LI (Ki-67 LI quotient ≤ 1), although this difference did not reach statistical significance ( p = 0.114, Fig. 6 ).

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EGFRvIII expression of 40.9% is slightly more than the mean expression reported in previous studies as mentioned above and although EGFRvIII expression showed borderline significance in Kaplan–Meier survival analysis, this did not hold up in univariate and multivariate analysis; thus, no clear statement can be made about a correlation between survival and EGFRvIII expression.

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