Challenges in Predicting the Change in the Cumulative Exposure of New Tobacco and Related Products Based on Emissions and Toxicity Dose-Response Data.

In practice, however, this would require data regarding clearly defined diseases, such as atherosclerosis, which is rare, while related endpoints, such as the pathology of the heart and vascular system, or blood cholesterol, usually did not show a significant trend in the studies we reviewed.

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