Physicochemical and biological impact of metal-catalyzed oxidation of IgG1 monoclonal antibodies and antibody-drug conjugates via reactive oxygen species.

MAbs · 2022 · PMC9519010 · PMID 36151884

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a clear trendno p-value reported

50 Herein, we report a metal ion-specific impact on product quality with a clear trend of structure-function relationship to both the mAbs (trastuzumab and antiNaPi2b) and their corresponding ADCs (T-DM1 and anti-NaPi2b-vc-MMAE).

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