Excessive fructose intake inhibits skeletal development in adolescent rats <i>via</i> gut microbiota and energy metabolism.

For the serum fructose level, there were no significant differences between the four groups, and the 20% FRU group showed a trend of higher levels when compared with the CON ( p = 0.13) and 10% GLU ( p = 0.28) groups.

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Although there were no significant differences between the control, 10% GLU, and 10% FRU groups, the 10% FRU group showed a trend of poor bone development, while the 10% GLU group showed a favorable trend of bone development.

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Through the Shannon species diversity index ( Figure 3D ), the diversity of fructose groups showed a decreasing trend as compared with the CON and 10% GLU groups.

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