Selective inhibition of soluble tumor necrosis factor signaling reduces abdominal aortic aneurysm progression.

TNFR1-positive cells were primarily limited to fibroblast-like cells in tunica adventitia of the aneurysmal wall ( Figure 7D , arrows) and TNFR1 aneurysmal contents showed a trend toward a 60% reduction after selective TNF inhibition with XPro1595 ( Figure 7D , graph), as also seen in the elastase induced aneurysms immunolabeling of TNFR2-positive cells was detected in leukocyte-like cells in tunica adventitia ( Figure 7E , arrows), but no difference in the levels of TNFR2 were detected after selective TNF inhibition ( Figure 7E , graph).

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