Both FAdV-4 and FAdV-8b viral genome copy numbers in the tissues of chickens from the inactivated rFAdV-4-fiber/8b vaccinated group were at similar levels to those in the corresponding tissues of chickens from unchallenged control groups, and the difference did not reach statistical significance.
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An inactivated novel chimeric FAdV-4 containing fiber of FAdV-8b provides full protection against hepatitis-hydropericardium syndrome and inclusion body hepatitis.
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p values less than 0.05 and 0.01 were considered statistically significant and extremely significant, respectively.
Since 2015, the clinical cases of HHS and IBH showed an increasing trend in China [ 38 , 39 ].