A machine learning model for grade 4 lymphopenia prediction during pelvic radiotherapy in patients with cervical cancer.

Although without statistical significance (p > 0.05), G4 ALC nadir showed a trend of promotion effects in the occurrence of local failure, regional lymph node metastasis, and distant metastasis after RT (OR, 1.41, 1.37, and 1.83, respectively) ( Figure 2C ). 3.3 Clinical and DVH characteristics and their correlations with G4 ALC nadir The clinical characteristics were compared between the patient groups with or without G4 ALC nadir, and the univariate analysis results (ORs and p-values) are listed in Supplementary Table S1 .

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Body mass index (BMI) had protective (OR, 0.9; p = 0.06) and pre-RT regional lymph node metastasis had promotive (OR, 2.22; p = 0.06) effects from the occurrence of G4 ALC nadir with borderline significance.

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