A pro-oxidant combination of resveratrol and copper down-regulates hallmarks of cancer and immune checkpoints in patients with advanced oral cancer: Results of an exploratory study (RESCU 004).

Front Oncol · 2022 · PMC9525028 · PMID 36185249

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highly significantno p-value reported

Combined statistical comparison of pre versus post treatment values of the four treatment groups with the control group using two-way ANOVA showed that R-Cu treatment had led to a highly significant up-regulation of all three antioxidant enzymes ( Figure 1 lower panels).

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did not reach statistical significanceno p-value reported

The exceptions were VEGFA (angiogenesis) and Glut1 (cellular energetics), where difference between pre and post values did not reach statistical significance.

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