Potential of the zebrafish (Danio rerio) embryo test to discriminate between chemicals of similar molecular structure-a study with valproic acid and 14 of its analogues.

Structure–activity relationship (SAR) Arranging the analogues by their EC 20 values (Table 4 ) in ascending order revealed a correlation between the molecular structure and the liver-altering potency: Non-branched monocarboxylic acids (hexanoic acid and 4-pentenoic acid; framed blue) were inactive, whereas dicarboxylic acids with shorter side chains (2-ethylbutytic acid, 2-methylhexanoic acid and 2-methylpentanoic acid; boxed yellow) as well as tricarboxylic acids with more short than long side chains (2,2-dimethylvaleric acid; framed green) showed a trend towards inactivity.

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