Associations between single-question Visual Analogue Scale pain score and weight-bearing and non-weight-bearing domains of Western Ontario and McMaster Universities Arthritis Index pain: data from 2 phase 3 clinical trials.

The mean divergence between VAS and WOMAC weight-bearing pain did not vary significantly with KL grade ( P = 0.72), but a highly significant trend was found for larger mean divergence in VAS and WOMAC non–weight-bearing pain with increasing KL grade ( P < 0.0001) (Figs. 3 A–C). 4.

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A significant trend was found for larger mean divergence in VAS and WOMAC pain with increasing KL grade ( P = 0.02), indicating that the more pronounced the structural knee OA damage becomes, the more VAS pain and WOMAC pain scales differ in the outcome they are measuring.

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