a clear trendP=0.053
Among non-diabetic patients, carriers of the major DPP4 haplotype had significantly lower levels of blood glucose (P=0.003), insulin (P=0.034), and HOMA-IR index (P=0.007) along with a clear trend for lower glycated hemoglobin (P=0.053), while DPP4 activity was very reduced (P=0.046).