SIRPα maintains macrophage homeostasis by interacting with PTK2B kinase in Mycobacterium tuberculosis infection and through autophagy and necroptosis.

Furthermore, we found that SIRPα expression in blood monocytes/macrophages could distinguish active PTB from latent MTB ( P = 0.0184, student t-test), NSCLC ( P < 0.001, student t-test), and infectious pneumonia (PA) subjects ( P = 0.0394, student t-test)), but the differences between PTB patients and extrapulmonary tuberculosis patients ( P = 0.1486, Mann-Whitney U-test) did not reach statistical significance ( Figure 1 f).

also in 111,027 other papers