Sex differences in inflammation in the hippocampus and amygdala across the lifespan in rats: associations with cognitive bias.

Young adult female rats had higher levels of IFN-γ, IL-1β, IL-6, and IL-10 than young adult males [IFN-γ ( p = 0.002; sex by age interaction: F(2,49) = 5.8003, p = 0.006, Ƞ p 2 = 0.191), IL-1β ( p = 0.005; sex by age interaction: F(2,47) = 3.622, p = 0.034, Ƞ p 2 = 0.134), IL-6 ( p = 0.001; sex by age interaction: F(2,46) = 8.44, p = 0.0008, Ƞ p 2 = 0.268), and IL-10 ( p = 0.024; sex by age interaction: F(2,49) = 3.828, p = 0.029, Ƞ p 2 = 0.135), IL-5 ( p = 0.0003; sex by age interaction approached significance: F(2,49) = 2.618, p = 0.08, Ƞ p 2 = 0.097), IL-13 ( p = 0.002; sex by age interaction: F(2,49) = 5.482, p = 0.007, Ƞ p 2 = 0.183)].

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