Remyelination varies between and within lesions in multiple sclerosis following bexarotene.

7 , 8 , 9 Within and between WM lesions there may be significant differences: combined PET‐MRI analyses show substantial heterogeneity of demyelination and remyelination in voxels from the same lesion, 10 and lesions close to the ventricles exhibit greater damage compared with those in deeper tissues, 11 , 12 , 13 , 14 although it is unknown if this gradient reflects greater damage as lesions form and evolve, or a lower potential to remyelinate.

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When the same lesions were segmented based on the baseline MTR quartile of each voxel, treatment effects in all segments did not reach statistical significance, and treatment effects were not significantly different between segments within pure WM, CGM or DGM lesions (Table 2 ).

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