The pleiotropic effects of α-thalassemia on HbSS and HbSC sickle cell disease: Reduced erythrocyte cation co-transport activity, serum erythropoietin, and transfusion burden, do not translate into increased survival.

However, in the HbSC cohort, there was a trend toward improved survival with fewer α‐globin genes, although this did not reach statistical significance (Figure 2D ). 4.

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α‐thalassemia did not influence survival in HbSS, but a nonsignificant trend was seen in those with HbSC.

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