A defect of amphiregulin release predicted longer survival independently of YAP expression in patients with pleural mesothelioma in the IFCT-0701 MAPS phase 3 trial.

Consistently, AREG depletion increased cell apoptosis, as assayed by measuring caspase‐3/7 activities (Figure 4Ai ‐iv), while significantly lowering proliferation of H2452, H28 and H2052 cells (Figure 4 Bii‐iv); a strong trend toward such an effect was observed for the MSTO‐211H cell line (Figure 4Bi ).

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