A Long-Term Safety and Efficacy Report on Intravitreal Delivery of Adipose Stem Cells and Secretome on Visual Deficits After Traumatic Brain Injury.

Transl Vis Sci Technol · 2022 · PMC9547363 · PMID 36180031

Europe PMC DOI

hedged sentences

0.0500

closest p · 1.0× alpha

0.0600

boldest claim

The sentences

failed to reach statistical significanceP > 0.05actually significant

Although the b-wave amplitude at the 1.0 cd · s · m 2 light intensity in the left eye of blast mice receiving ASC-CCM demonstrated significant improvement, the left eyes of those mice receiving ASCs failed to reach statistical significance compared to blast mice receiving saline injections (ASCs 414.01 ± 11.3 vs. blast-saline 404.71 ± 17.37 μV at 1.0 cd · s · m 2 , P > 0.05; ASC-CCM 430.01 ± 9.16 vs. blast-saline 404.71 ± 17.37 μV at 1.0 cd · s · m 2 , P < 0.05).

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a trend toward significanceP = 0.06so close (0.05 < p ≤ 0.1)

blast-saline: 0.320 ± 0.0 c/d, P < 0.001) with a trend toward significance at 10 months after blast injury that is not significantly different than in Sham mice (10 months: 0.450 ± 0.02 vs. blast-saline: 0.398 ± 0.0 c/d, P = 0.06; vs. sham-saline: 0.480 ± 0.01 c/d, P > 0.05).

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