Whole genome analysis in APOE4 homozygotes identifies the DAB1-RELN pathway in Alzheimer's disease pathogenesis.

Neurobiol Aging · 2022 · PMC9548409 · PMID 35977442

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

0.0240

boldest claim

The sentences

highly significantp = 7.8 × 10 −10actually significant

The result for the same risk allele (T) remained highly significant (Hazard Ratio=2.27, CI = 1.75–2.95, p = 7.8 × 10 −10 ).

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nominally significantp = 0.024actually significant

Weaker but nominally significant associations with the consistent direction of the effect were also observed in the APH1B ( p = 0.024), BIN1 ( p = 0.011), SEC61G ( p = 0.015) and SNX1 ( p = 0.048) genes.

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almost significantlyno p-value reported

We found that they were almost significantly enriched for genes associated to AD in the APOE- ε4 homozygotes ( p values 0.061, 0.077, 0.083, for the receptor complex and branches 1 and 2, respectively).

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