Barely Significant
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Randomized, placebo controlled phase I trial of the safety, pharmacokinetics, pharmacodynamics and acceptability of a 90 day tenofovir plus levonorgestrel vaginal ring used continuously or cyclically in women: The CONRAD 138 study.

PLoS One · 2022 · PMC9550080 · PMID 36215267

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This did not reach statistical significance possibly due to the high inter and intra assay variability reported in p24 antigen production in ex vivo biopsy challenge experiments, especially at baseline and the small sample size [ 68 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.